This schedule is the one I recommend, and it should not be interpreted to mean that other protocols recommended by a veterinarian would be less satisfactory. It's a matter of professional judgment and choice. The following protocol is particularly recommended for breeds or families of dogs susceptible to or affected with immune dysfunction, immune-mediated disease, immune-reactions associated with vaccinations or autoimmune endocrine disease.
| 6 weeks | Distemper & Measles |
| 71/2 weeks | Killed or modified-live (MLV) parvovirus |
| OR | |
| 8 weeks | Distemper & parvovirus. Maybe hepatitis. Maybe parainfluenza |
| 10 weeks | Distemper and parvovirus. Maybe hepatitis. Maybe parainfluenza |
| THEN | |
| 12 weeks | Distemper, Maybe hepatitis. Maybe parainfluenza |
| 14 weeks | Distemper, and killed or MLV parvovirus* Maybe hepatitis. Maybe parainfluenza |
| 18-20 weeks | Distemper, and killed or MLV parvovirus* Maybe hepatitis. Maybe parainfluenza |
| 16-24 weeks | Killed rabies vaccine given at least 2 weeks after last Distemper/Parvo |
| * During parvovirus epidemics or for highly susceptible breeds such as Rottweilers, newer modified-live (MLV) vaccines that provide more complete immunity and override maternal immunity are available |